High affinity human mGlu5
receptor antagonist (Ki
= 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5
= 2.3 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies.
Hintermann et al.