Chemical Name: 3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
Biological ActivityHigh affinity human mGlu 5 receptor antagonist (K i = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu 5 receptors (IC 50 = 2.3 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies.
Hintermann et al.
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