ABT 594 hydrochloride
Chemical Name: (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride
Biological ActivityABT 594 hydrochloride is a selective α4β2 nAChR agonist (EC50 = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.
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ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.
Donnelly-Roberts et al.
ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model.
Lynch et al.
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
Munro et al.
MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs.
Mar et al.
Psychopharmacology (Berl), 2017;234:2837
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