ABT 594 hydrochloride

Catalog # Availability Size / Price Qty
6576/10
6576/50
Cat.No. 6576 - ABT 594 hydrochloride | C9H11ClN2O.HCl | CAS No. 203564-54-9
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Description: Selective α4β2 nAChR agonist
Alternative Names: Tebanicline

Chemical Name: (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Selective α4β2 nAChR agonist (EC50 = 140 nM for human α4β2 nAChRs, in vitro). Exhibits >900-fold selectivity for α4β2 nAChRs over other neurotransmitter receptors. Displays analgesic properties in various animal models of pain. Potentiates gabapentin mediated analgesia. Also demonstrates cognitive enhancement effects in rodent model of attention deficit.

Technical Data

M.Wt:
235.11
Formula:
C9H11ClN2O.HCL
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
203564-54-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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