ABT 639

Key Product Details

Product Description

ABT 639 is a Ca_V3.2 channel blocker (IC₅₀ = 2.3 μM). Also blocks low voltage-activated (Ca_V3.1) currents in native rat DRG neurons (IC₅₀ = 7.6 μM). Exhibits little or no activity at other ion channels and receptors. Displays antinociceptive effects in a mechanical hyperalgesia model in vivo. Orally bioavailable.

Product Specifications for ABT 639

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ABT 639

The following data is based on the product molecular weight 455.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.97 mL	54.84 mL	109.67 mL
1 mM	2.19 mL	10.97 mL	21.93 mL
2 mM	1.10 mL	5.48 mL	10.97 mL
10 mM	0.22 mL	1.10 mL	2.19 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Zhang Optimization of ADME properties for sulfonamides leading to the discovery of a T-type calcium channel blocker, ABT-639. ACS Med.Chem.Lett. 2015 PMID: 26101566

Product Documents for ABT 639