ABT 702 hydrochloride

Key Product Details

Product Description

ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC₅₀ = 1.7 nM), selective over other sites of adenosine interaction (A₁, A_2A and A₃ receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Product Specifications for ABT 702 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ABT 702 hydrochloride

The following data is based on the product molecular weight 499.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	10.00 mL	20.01 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Kowaluk ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 2000 PMID: 11082454
• Lee Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 2001 PMID: 11405650
• Jarvis ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive J.Pharmacol.Exp.Ther. 2000 PMID: 11082453

Product Documents for ABT 702 hydrochloride