ABT 737

Catalog # Availability Size / Price Qty
6835/10
6835/50
ABT 737 | CAS No. 852808-04-9 | Bcl-2 Family Inhibitors
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Description: Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

Chemical Name: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

Purity: ≥98%

Product Details
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Biological Activity

High affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

Technical Data

M.Wt:
813.43
Formula:
C42H45ClN6O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
852808-04-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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