ABT 737

Key Product Details

Product Description

ABT 737 is a high affinity Bcl-2 family inhibitor (K_i ≤ 1nM for Bcl-X_L, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC₅₀ < 1 μM) and multiple myeloma cells (IC₅₀ = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

Product Specifications for ABT 737

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ABT 737

The following data is based on the product molecular weight 813.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.23 mL	6.15 mL	12.29 mL
5 mM	0.25 mL	1.23 mL	2.46 mL
10 mM	0.12 mL	0.61 mL	1.23 mL
50 mM	0.02 mL	0.12 mL	0.25 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• van Delft, MF The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell. 2006 PMID: 17097561
• Kline ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia 2007 PMID: 17460700
• Oltersdorf An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 2005 PMID: 15902208

Product Documents for ABT 737