AC 186

Catalog # Availability Size / Price Qty
5053/10
5053/50
Cat.No. 5053 - AC 186 | C18H17F3O | CAS No. 1421854-16-1
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Description: Potent and selective ERβ agonist; neuroprotective

Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol

Purity: ≥99%

Product Details
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Biological Activity

Potent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.

Technical Data

M.Wt:
306.32
Formula:
C18H17F3O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1421854-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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