Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Biological ActivityPotent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.
George et al.
ACS Chem.Neurosci., 2013;4:1537
AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model.
McFarland et al.
ACS Chem.Neurosci., 2013;4:1249
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