Chemical Name: 4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Biological ActivityPotent and selective ERβ agonist (EC50 values are 6 and 5000 nM for ERβ and ERα respectively). Exhibits gender selective neuroprotective effects in a male rat model of Parkinson's disease. Decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer's disease.
George et al.
ACS Chem.Neurosci., 2013;4:1537
AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model.
McFarland et al.
ACS Chem.Neurosci., 2013;4:1249
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