AC 253
Discontinued Product
6550 has been discontinued.
View all Calcitonin and Related Receptor Agonists products.
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Description: Amylin (AMY3) antagonist
Biological Activity
AC 253 is an amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.Technical Data
M.Wt:
2847.11
Formula:
C122H196N40O39
Sequence:
LGRLSQELHRLQTYPRTNTGSNTY
(Modifications: Leu-1 = N-terminal Ac, Tyr-24 = C-terminal amide)
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
151804-79-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity.
Coppock et al.
Biochem.J., 1999;338:15 -
Actions of β-amyloid protein on human neurons are expressed through the amylin receptor.
Jhamandas et al.
Am.J.Pathol., 2011;178:140 -
Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.
Fu et al.
J,Biol.Chem., 2012;287:18820
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