Ac-FLTD-CMK

Tocris Bioscience | Catalog # 7242

Potent and selective inhibitor of caspases 1, 5 and 4
Tocris Bioscience

Key Product Details

Description

Potent and selective inhibitor of caspases 1, 5 and 4
View all Caspase Inhibitors »

Product Description

Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.

Product Specifications for Ac-FLTD-CMK

Molecular Weight

569.05

Formula

C26H37ClN4O8

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

2376255-48-8

PubChem ID

155906572

InChI Key

UCWNTWGHVCSMJP-WPUDHWPRSA-N

SMILES

O=C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in DMSO

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ac-FLTD-CMK

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ac-FLTD-CMK

For research use only

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