Caspase Inhibitors: Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

"Caspase Inhibitors" has 19 results in Products.
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Z-VAD-FMK 

Cell-permeable, irreversible caspase inhibitor

CY 09 

NLRP3 inhibitor; active in vivo

Z-DEVD-FMK 

Cell-permeable, irreversible caspase-3 inhibitor

INF 4E 

Caspase-1 and NLRP3 inflammasome inhibitor

INF 39 

Irreversible NLRP3 inhibitor

VX 765 

High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
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