Caspase Inhibitors: Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

"Caspase Inhibitors" has 21 results in Products.
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Z-VAD-FMK

Cell-permeable, irreversible caspase inhibitor

Caspase Inhibitor Sampler Pack

100 ug each of Z-VAD-FMK, Z-WEHD-FMK, Z-VDVAD-FMK, Z-DEVD-FMK, Z-YVAD-FMK, Z-VEID-FMK, Z-IETD-FMK, Z-LEHD-FMK, Z-AEVD-FMK, and Z-LEED-FMK

Z-DEVD-FMK

Cell-permeable, irreversible caspase-3 inhibitor

AZ 10417808

Selective non-peptide caspase-3 inhibitor

INF 4E

Caspase-1 and NLRP3 inflammasome inhibitor

Z-DQMD-FMK

Caspase-3 inhibitor

INF 39

Irreversible NLRP3 inhibitor

CY 09

NLRP3 inhibitor; active in vivo
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