Chemical Name: N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
Biological ActivityAcetazolamide is a carbonic anhydrase inhibitor. Modulates epileptiform synchronization in rat brain slices. Increases speed of synaptic vesicle recycling and changes synaptic performance in ex vivo murine neuromuscular junction. Lowers intracranial pressure in healthy rats. Also potentiates the antitumor effects of the HDAC inhibitor MS 275 (Cat. No. 6208).
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Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma.
Bayat et al.
BMC Cancer., 2017;17:156
Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats.
Uldall et al.
Carbonic anhydrase inhibitor acetazol. shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction.
Bertone et al.
Carbonic anhydrase inhibition by acetazol. reduces in vitro epileptiform synchronization.
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