MS 275

Tocris Bioscience | Catalog # 6208

HDAC (Class I) inhibitor
Tocris Bioscience

Key Product Details

Description

HDAC (Class I) inhibitor

Alternative Names

entinostat,SNDX 275
View all Class I Histone Deacetylases Inhibitors »

Product Description

MS 275 is a class I HDAC inhibitor (IC50 values are 0.18, 0.74, 44.9 and >100 μM for HDAC1, 3, 8 and 6, respectively). Exhibits antiproliferative effects and induces apoptosis in a range of tumor cell lines in vitro and in vivo. Increases estrogen receptor α- and aromatase expression in breast cancer cells. Inhibits PCB-induced neuronal cell death by preventing HDAC3 binding and histone deacetylation within the synapsin-1 promoter.

Product Specifications for MS 275

Molecular Weight

376.41

Formula

C21H20N4O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate

CAS Number

209783-80-2

PubChem ID

4261

InChI Key

INVTYAOGFAGBOE-UHFFFAOYSA-N

SMILES

O=C(C1=CC=C(C=C1)CNC(OCC2=CN=CC=C2)=O)NC3=CC=CC=C3N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.64 100

Preparing Stock Solutions for MS 275

The following data is based on the product molecular weight 376.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.57 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

Calculators

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Product Documents for MS 275

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MS 275

For research use only

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  • TGF beta high responder treated with 1.5 μM MS 275 (HDAC 3 inhibitor) for 48 h. Cell lysates were analysed by western blot.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: C3-TAg tumour cell
    Verified Customer | Posted 11/15/2019
    TGF beta high responder treated with 1.5 μM MS 275 (HDAC 3 inhibitor) for 48 h. Cell lysates were analysed by western blot.
    MS 275 6208

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