MS 275

Catalog # Availability Size / Price Qty
6208/50
6208/10
MS 275 | CAS No. 209783-80-2 | Class I Histone Deacetylases Inhibitors
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Description: HDAC (Class I) inhibitor
Alternative Names: entinostat, SNDX 275

Chemical Name: (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate

Purity: ≥99%

Product Details
Citations (1)
Reviews

Biological Activity

MS 275 is a class I HDAC inhibitor (IC50 values are 0.18, 0.74, 44.9 and >100 μM for HDAC1, 3, 8 and 6, respectively). Exhibits antiproliferative effects and induces apoptosis in a range of tumor cell lines in vitro and in vivo. Increases estrogen receptor α- and aromatase expression in breast cancer cells. Inhibits PCB-induced neuronal cell death by preventing HDAC3 binding and histone deacetylation within the synapsin-1 promoter.

Technical Data

M.Wt:
376.41
Formula:
C21H20N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
209783-80-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for MS 275

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