Acifran

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1762/10
1762/50
Acifran | CAS No. 72420-38-3 | Nicotinic Acid Receptor (GPR109) Agonists
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Description: Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
Alternative Names: AY 25712

Chemical Name: 4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid

Purity: ≥99%

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Biological Activity

Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50 values are 1.3 and 4.2 μM respectively). Reduces serum triglycerides and circulating LDL-cholesterol in vivo, without affecting liver weight or liver enzymes.

Technical Data

M.Wt:
218.21
Formula:
C12H10O4
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
72420-38-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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