The low affinity and high affinity receptors for nicotinic acid (niacin) are the inhibitory G-protein coupled receptors HM74/GPR109B and HM74A/GPR109A, respectively. Binding of niacin to HM74A mediates an anti-lipolytic effect observed on adipose tissue. HM74A is also expressed on mouse splenocytes, as niacin and other vitamins can enhance the mitogenic response of lymphocytes.
Human HM74A/GPR109A (NP_808219) VersaClone cDNA
R&D Systems | Catalog # RDC0144
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Background: HM74A/PUMA-G/GPR109A
Long Name
G Protein-coupled Receptor HM74A/G Protein-coupled Receptor 109A
Alternate Names
GPR109A, HCA2, HCAR2, Niacr1, Nicotinic Acid Receptor, PUMAG
Gene Symbol
HCAR2
UniProt
Additional HM74A/PUMA-G/GPR109A Products
Product Documents for Human HM74A/GPR109A (NP_808219) VersaClone cDNA
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Product Specific Notices for Human HM74A/GPR109A (NP_808219) VersaClone cDNA
For research use only
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