Potent, dual orexin receptor antagonist (IC50
values are 11 and 60 nM for OX2
receptors respectively). Exhibits anxiolytic-like properties in vivo
. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist.
Boss et al.