Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.
Soluble to 50 mM in DMSO
Desiccate at +4°C
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A kinetic study on the mechanism of inhibition of RNA synthesis catalyzed by DNA-dependent RNA polymerase. Differences in inhibition by ethidium bromide, 3,8-diamino-6-ethylphenanthridinium bromide and actinomycin D.
Aktipis et al.
Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle.
Glynn et al.
The mechanism of actinomycin D-mediated inhibition of HIV-1 reverse transcription.
Jeeninga et al.
Nucleic Acids Res., 1998;26:5472
The citations listed below are publications that use Tocris products. Selected citations for Actinomycin D include:
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