Actinomycin D

  ( 16 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1229
Chemical Name:2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Product Details
Citations (16)
Reviews
Biological Activity
Anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.
Technical Data
  • M.Wt:
    1255.43
  • Formula:
    C62H86N12O16
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    50-76-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Actinomycin D include:

16 Citations: Showing 1 - 10
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  1. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
    Authors: Thomson Et al.
    Neuron  2017;95:550
  2. Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
    Authors: Di Et al.
    J.Neurosci.  2016;36:8461
  3. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  5. Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions.
    Authors: Parker and Kooi
    J Biol Chem  2014;453:42525
  6. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Authors: Gutierrez Et al.
    J Biol Chem  2014;289:33568
  7. Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
    Authors: Podszywalow-Bartnicka Et al.
    Cardiovasc Res  2014;13:3727
  8. Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.
    Authors: Yuan and Burrell
    J Neurosci  2013;33:4349
  9. Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
    Authors: Kang Et al.
    J Neurosci  2012;32:9277
  10. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
    Authors: Cheang Et al.
    Biochem Biophys Res Commun  2011;92:267
  11. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
    Authors: Tian Et al.
    Mol Cell Neurosci  2010;44:94
  12. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  13. Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase.
    Authors: Backlund Et al.
    Nucleic Acids Res  2009;37:2346
  14. Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
    Authors: Wong Et al.
    Circ Res  2009;104:228
  15. p100 increases AT1R expression through interaction with AT1R 3'-UTR.
    Authors: Paukku Et al.
    Nucleic Acids Res  2008;36:4474
  16. Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
    Authors: Chan Et al.
    Cell Cycle  2007;282:4585
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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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