Chemical Name: 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13] oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Biological ActivityActinomycin D is an anti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.
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A kinetic study on the mechanism of inhibition of RNA synthesis catalyzed by DNA-dependent RNA polymerase. Differences in inhibition by ethidium bromide, 3,8-diamino-6-ethylphenanthridinium bromide and actinomycin D.
Aktipis et al.
Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle.
Glynn et al.
The mechanism of actinomycin D-mediated inhibition of HIV-1 reverse transcription.
Jeeninga et al.
Nucleic Acids Res., 1998;26:5472
Citations for Actinomycin D
The citations listed below are publications that use Tocris products. Selected citations for Actinomycin D include:
19 Citations: Showing 1 - 10
Structural determinants and genetic modifications enhance BMP2 stability and extracellular secretion.
Authors: Khattar Et al.
FASEB Bioadv 2019;1:180
Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons.
Authors: Livingstone Et al.
Front Mol Neurosci 2019;12:198
Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.
Authors: Thomson Et al.
Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala.
Authors: Di Et al.
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
Authors: Wang Et al.
PLoS One 2014;8:e83941
Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions.
Authors: Parker and Kooi
J Biol Chem 2014;453:42525
The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
Authors: Gutierrez Et al.
J Biol Chem 2014;289:33568
Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation.
Authors: Podszywalow-Bartnicka Et al.
Cardiovasc Res 2014;13:3727
Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated presynaptic and postsynaptic transcription and translation.
Authors: Yuan and Burrell
J Neurosci 2013;33:4349
Loss of neuron-astroglial interaction rapidly induces protective CNTF expression after stroke in mice.
Authors: Kang Et al.
J Neurosci 2012;32:9277
Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
Authors: Cheang Et al.
Biochem Biophys Res Commun 2011;92:267
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
Authors: Tian Et al.
Mol Cell Neurosci 2010;44:94
Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
Posttranscriptional regulation of angiotensin II type 1 receptor expression by glyceraldehyde 3-phosphate dehydrogenase.
Authors: Backlund Et al.
Nucleic Acids Res 2009;37:2346
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
Authors: Wong Et al.
Circ Res 2009;104:228
p100 increases AT1R expression through interaction with AT1R 3'-UTR.
Authors: Paukku Et al.
Nucleic Acids Res 2008;36:4474
Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
Authors: Chan Et al.
Cell Cycle 2007;282:4585
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation.
Authors: Vecsey Et al.
J Neurosci 2007;27:6128
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