(±)-ADX 71743

Key Product Details

Product Description

(±)-ADX 71743 is a negative allosteric modulator at mGlu₇ (IC₅₀ = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Product Specifications for (±)-ADX 71743

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (±)-ADX 71743

The following data is based on the product molecular weight 269.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.71 mL	18.56 mL	37.13 mL
5 mM	0.74 mL	3.71 mL	7.43 mL
10 mM	0.37 mL	1.86 mL	3.71 mL
50 mM	0.07 mL	0.37 mL	0.74 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Tassin Phasic and tonic mGlu₇ receptor activity modulates the thalamocortical network. Front Neural Circuits 2016 PMID: 27199672
• Klar Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 2015 PMID: 25972184

Product Documents for (±)-ADX 71743