(±)-ADX 71743

Catalog # Availability Size / Price Qty
5715/10
5715/50
Cat.No. 5715 - (�)-ADX 71743 | C17H19NO2
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Description: Negative allosteric modulator of mGlu7; brain penetrant

Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone

Purity: ≥98%

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Biological Activity

Negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Technical Data

M.Wt:
269.34
Formula:
C17H19NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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