Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone
Biological Activity(±)-ADX 71743 is a negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus.
Klar et al.
Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network.
Tassin et al.
Front Neural Circuits, 2016;10:31
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for (±)-ADX 71743
There are currently no reviews for this product. Be the first to review (±)-ADX 71743 and earn rewards!
Have you used (±)-ADX 71743?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image