AEE 788

Tocris Bioscience | Catalog # 5318

Potent EGFR and VEGFR inhibitor
Tocris Bioscience

Key Product Details

Description

Potent EGFR and VEGFR inhibitor
View all EGF Receptor Inhibitors »

Product Description

AEE 788 is a potent EGFR and VEGFR inhibitor (IC50 values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC50 values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

Product Specifications for AEE 788

Molecular Weight

440.58

Formula

C27H32N6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

CAS Number

497839-62-0

PubChem ID

10297043

InChI Key

OONFNUWBHFSNBT-HXUWFJFHSA-N

SMILES

C[C@@H](NC2=C(C=C(C4=CC=C(CN5CCN(CC)CC5)C=C4)N3)C3=NC=N2)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.06 100

Preparing Stock Solutions for AEE 788

The following data is based on the product molecular weight 440.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.70 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Calculators

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Product Documents for AEE 788

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AEE 788

For research use only

Customer Reviews for AEE 788 (2)

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  • Inhibits proliferation
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: EGFR-hi cells
    Verified Customer | Posted 09/17/2022
    Used this to inhibit proliferation, looks great!
    AEE 788 5318
  • In vitro culture
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Verified Customer | Posted 08/05/2018
    Used in vitro to investigate ERG pathway in connection with VGEF

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