Catalog Number: 0414
Alternate Names: Tyrphostin AG 490
Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
Biological Activity
Selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.
    Abe et al.
    Int.Immunopharmacol., 2009;9:870
  2. Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
    Gazit et al.
    J.Med.Chem., 1991;34:1896
  3. Inhbition of acute lymphoblastic leukaemia by a JAK-2 inhibitor.
    Meydan et al.
    Nature, 1996;379:645
  4. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
    Wang et al.
    J.Immunol., 1999;162:3897
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