AG 490

Catalog # Availability Size / Price Qty
0414/10
0414/50
AG 490 | CAS No. 133550-30-8 | EGF Receptor Inhibitors
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Description: EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
Alternative Names: Tyrphostin AG 490

Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

Purity: ≥99%

Product Details
Citations (14)
Supplemental Products
Reviews

Biological Activity

Selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.

Technical Data

M.Wt:
294.31
Formula:
C17H14N2O3
Solubility:
Soluble to 20 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
133550-30-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AG 490

The citations listed below are publications that use Tocris products. Selected citations for AG 490 include:

14 Citations: Showing 1 - 10

  1. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
    Authors: Azad Et al.
    EMBO Mol Med  2017;9:167
  2. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.
    Authors: Shenoy Et al.
    Neuropsychopharmacology  2015;34:1180
  3. Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
    Authors: Zhao Et al.
    J Transl Med  2015;16:27411
  4. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.
    Authors: Tactacan Et al.
    Mol Cancer  2015;14:139
  5. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells.
    Authors: Jiang Et al.
    PLoS One  2015;13:280
  6. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    EMBO J  2015;10:e0143319
  7. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  8. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
    Authors: Park Et al.
    Neuron  2013;38:1426
  9. PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
    Authors: Doulatov Et al.
    Genes Dev  2009;23:2076
  10. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
    Authors: Jung Et al.
    Carcinogenesis  2008;29:713

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