AG 490

  ( 11 citations )    
Product Datasheet
Catalog Number:0414
Alternate Names:Tyrphostin AG 490
Chemical Name:(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo.
Technical Data
  • M.Wt:
    294.31
  • Formula:
    C17H14N2O3
  • Solubility:
    Soluble to 20 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    133550-30-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AG 490 include:

11 Citations: Showing 1 - 10
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  1. PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.
    Authors: Azad Et al.
    EMBO Mol Med  2017;9:167
  2. Let-7 and miR-125 cooperate to prime progenitors for astrogliogenesis.
    Authors: Shenoy Et al.
    Neuropsychopharmacology  2015;34:1180
  3. Evodiamine Induces Apoptosis and Inhibits Migration of HCT-116 Human Colorectal Cancer Cells.
    Authors: Zhao Et al.
    J Transl Med  2015;16:27411
  4. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.
    Authors: Tactacan Et al.
    Mol Cancer  2015;14:139
  5. YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells.
    Authors: Jiang Et al.
    PLoS One  2015;13:280
  6. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    EMBO J  2015;10:e0143319
  7. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  8. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.
    Authors: Park Et al.
    Neuron  2013;38:1426
  9. PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
    Authors: Doulatov Et al.
    Genes Dev  2009;23:2076
  10. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
    Authors: Jung Et al.
    Carcinogenesis  2008;29:713
  11. Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.
    Authors: Bellik Et al.
    Br J Pharmacol  2005;146:568
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