Selective inhibitor of EGF receptor tyrosine kinase (IC50
values are 2 and 13.5 μ
M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro
and tumor cell invasion in vivo
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All Tocris products are intended for laboratory research use only.
The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.
Abe et al.
Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
Gazit et al.
Inhbition of acute lymphoblastic leukaemia by a JAK-2 inhibitor.
Meydan et al.
JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
Wang et al.
The citations listed below are publications that use Tocris products. Selected citations for AG 490 include:
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