Chemical Name: 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide
Biological ActivityAH 7614 is a selective free fatty acid receptor 4 (FFA4/GPR120) antagonist (pIC50 values are 7.1 and <4.6 for human FFA4 and FFA1 receptors respectively). Inhibits linoleic acid and GSK 137647A-induced intracellular calcium accumulation in U2OS osteosarcoma cells expressing the FFA4 receptor.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
Sparks et al.
Citations for AH 7614
The citations listed below are publications that use Tocris products. Selected citations for AH 7614 include:
2 Citations: Showing 1 - 2
Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation.
Authors: Kishikawa Et al.
Front Endocrinol (Lausanne) 2019;10:157
Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.
Authors: Chen Et al.
Mol Med 2018;24:60
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