AIM 100

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4946/10
4946/50
AIM 100 | CAS No. 873305-35-2 | Ack1 Inhibitors
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Description: Potent and selective Ack1 (TNK2) inhibitor

Chemical Name: 5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice. Also promotes DAT endocytosis and oligomerization.

Technical Data

M.Wt:
371.43
Formula:
C23H21N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
873305-35-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for AIM 100

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Inhibition of MEK and ACK1 suppresses long-term growth of WM209 and SK-MEL-23 cells.
By Anonymous on 11/09/2019
Application: Species: Human

Combined pharmacological inhibition of MEK and ACK1 suppresses long-term growth of WM209 and SK-MEL-23 cells.

PMID: 29133622

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