AIM 100

Catalog # Availability Size / Price Qty
4946/10
4946/50
Cat.No. 4946 - AIM 100 | C23H21N3O2 | CAS No. 873305-35-2
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Description: Potent and selective Ack1 (TNK2) inhibitor

Chemical Name: 5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

Purity: ≥98%

Product Details
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Biological Activity

Potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.

Technical Data

M.Wt:
371.43
Formula:
C23H21N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
873305-35-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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