Biological Activity Potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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For batch specific data refer to the Certificate of Analysis.
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