AIM 100

Tocris Bioscience | Catalog # 4946

Potent and selective Ack1 (TNK2) inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective Ack1 (TNK2) inhibitor
View all Ack1 Inhibitors »

Product Description

AIM 100 is a potent Ack1 (TNK2) inhibitor (IC50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice. Also promotes DAT endocytosis and oligomerization.

Product Specifications for AIM 100

Molecular Weight

371.43

Formula

C23H21N3O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

CAS Number

873305-35-2

PubChem ID

11501591

InChI Key

XNFHHOXCDUAYSR-SFHVURJKSA-N

SMILES

C1(C(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)=C3N=CN=C1NC[C@H]2OCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.14 100
Ethanol 37.14 100

Preparing Stock Solutions for AIM 100

The following data is based on the product molecular weight 371.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for AIM 100

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AIM 100

For research use only

Customer Reviews for AIM 100 (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used AIM 100?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Inhibition of MEK and ACK1 suppresses long-term growth of WM209 and SK-MEL-23 cells.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: WM209 and SK-MEL-23 cells
    Verified Customer | Posted 11/09/2019
    Combined pharmacological inhibition of MEK and ACK1 suppresses long-term growth of WM209 and SK-MEL-23 cells.
    AIM 100 4946

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All