Catalog Number: 5773
Chemical Name: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one
Biological Activity
Potent and selective dual Akt1 and 2 inhibitor (IC50 values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Active in vivo.
Technical Data
  • M.Wt:
    551.64
  • Formula:
    C34N29N7O
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    612847-09-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members.
    DeFeo-Jones D et al.
    Mol.Cancer Ther., 2005;4:271
  2. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.
    Barnett et al.
    Biochem. J., 2005;385:399
  3. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
    Lindsley et al.
    Bioorg.Med.Chem.Lett., 2005;15:761
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch:

Feedback

Customer Information