Akti-1/2

Catalog # Availability Size / Price Qty
5773/10
5773/50
Akt (Protein Kinase B) Inhibitors Small Molecule
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Description: Potent and selective dual Akt1 and 2 inhibitor

Chemical Name: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

Purity: ≥98%

Product Details
Supplemental Products
Reviews (2)

Biological Activity

Potent and selective dual Akt1 and 2 inhibitor (IC50 values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Active in vivo.

Technical Data

M.Wt:
551.64
Formula:
C34N29N7O
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
612847-09-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Average Rating: 4.5 (Based on 2 Reviews)

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Akti-1/2 blocks LPA-mediated COX-2 expression
By Peter Cruz on 12/13/2018
Species: Human

Human osteosarcoma cells were incubated with 10 μM Akti-1/2 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Akti-1/2 abolished LPA-induced COX-2 expression.


Akt-1/2 blocks 15d-PGJ2-induced Akt phosphorylation
By Christopher Trummer on 10/15/2018
Species: Human

MG-63 cells were incubated with PD169316 (25 μM), LY294002 (10 μM) or Akt-1/2 (5 μM Akt-I) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 1 h to follow pAkt expression using Western blot. Akt-1/2 completely blocked 15d-PGJ2-induced Akt phosphorylation in MG-63 cells.


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