AL 8697

Key Product Details

Product Description

AL 8697 is a potent and selective p38α inhibitor (IC₅₀ = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.

Product Specifications for AL 8697

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AL 8697

The following data is based on the product molecular weight 402.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.43 mL	24.85 mL
5 mM	0.50 mL	2.49 mL	4.97 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Aiguadé Novel triazolopyridylbenzamides as potent and selective p38&#945 inhibitors. Bioorg.Med.Chem.Lett. 2012 PMID: 22521646
• Balagué Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 2012 PMID: 22229697

Product Documents for AL 8697