Catalog Number: 2142
Biological Activity
Highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
Technical Data
  • M.Wt:
    2857.28
  • Formula:
    C120H206N44O35S
  • Sequence:
    RSGPPGLQGRAQRLLQASGNHAAGILTM

    (Modifications: Met-28 = C-terminal amide)

  • Solubility:
    Soluble to 0.30 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    532932-99-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B.
    Asahi et al.
    Bioorg.Med.Chem.Lett., 2003;13:111
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:

4 Citations: Showing 1 - 4
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  1. Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse.
    Authors: Moore Et al.
    Respir Physiol Neurobiol 2014;200:118
  2. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res 2012;318:2004
  3. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.
    Authors: Shahid Et al.
    Br J Pharmacol 2012;165:2292
  4. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
    Authors: Malherbe Et al.
    Br J Pharmacol 2009;156:1326

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