Biological Activity[Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
(Modifications: Met-28 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B.
Asahi et al.
Citations for [Ala11,D-Leu15]-Orexin B
The citations listed below are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:
4 Citations: Showing 1 - 4
Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse.
Authors: Moore Et al.
Respir Physiol Neurobiol 2014;200:118
OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
Authors: Guo and Feng
Exp Cell Res 2012;318:2004
Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.
Authors: Shahid Et al.
Br J Pharmacol 2012;165:2292
Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
Authors: Malherbe Et al.
Br J Pharmacol 2009;156:1326
No product specific FAQs exist for this product, however you mayView all Peptide FAQs
VersaClone cDNA Plasmids
Reviews for [Ala11,D-Leu15]-Orexin B
There are currently no reviews for this product. Be the first to review [Ala11,D-Leu15]-Orexin B and earn rewards!
Have you used [Ala11,D-Leu15]-Orexin B?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image