Biological ActivityHighly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
(Modifications: Met-28 = C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B.
Asahi et al.
Citations for [Ala11,D-Leu15]-Orexin B
The citations listed below are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:
4 Citations: Showing 1 - 4
Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse.
Authors: Moore Et al.
Respir Physiol Neurobiol 2014;200:118
OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
Authors: Guo and Feng
Exp Cell Res 2012;318:2004
Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.
Authors: Shahid Et al.
Br J Pharmacol 2012;165:2292
Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
Authors: Malherbe Et al.
Br J Pharmacol 2009;156:1326
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