[Ala11,D-Leu15]-Orexin B

  ( 4 citations )    
Product Datasheet
Catalog Number:2142
Chemical Name:
Product Details
Citations (4)
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Biological Activity
Highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.
Technical Data
  • M.Wt:
    2857.28
  • Formula:
    C120H206N44O35S
  • Sequence:
    RSGPPGLQGRAQRLLQASGNHAAGILTM

    (Modifications: Met-28 = C-terminal amide)

  • Solubility:
    Soluble to 0.30 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    532932-99-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for [Ala11,D-Leu15]-Orexin B include:

4 Citations: Showing 1 - 4
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  1. Effects of orexin 2 receptor activation on apnea in the C57BL/6J mouse.
    Authors: Moore Et al.
    Respir Physiol Neurobiol  2014;200:118
  2. OX2R activation induces PKC-mediated ERK and CREB phosphorylation.
    Authors: Guo and Feng
    Exp Cell Res  2012;318:2004
  3. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.
    Authors: Shahid Et al.
    Br J Pharmacol  2012;165:2292
  4. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
    Authors: Malherbe Et al.
    Br J Pharmacol  2009;156:1326

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VersaClone cDNA Plasmids
Description Application Cat# Citations Images  

Human Orexin R2/HCRTR2 (AAC39602) VersaClone cDNA

RDC0522
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Mouse Orexin R2/HCRTR2 (NP_945200) VersaClone cDNA

RDC0617
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