[Ala92]-p16 (84-103)
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Description: Cdk 4 inhibitor peptide; derived from p16
Biological Activity
[Ala92]-p16 (84-103) is a peptide derived from the tumor suppressor protein p16; inhibits cyclin-dependent kinase-4 (cdk4)/cyclin D1 (IC50 ~ 1.5 μM) and binds to cdk6.Technical Data
M.Wt:
2123.44
Formula:
C93H155N31O26
Sequence:
DAAREGFLATLVVLHRAGAR
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
189064-08-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule.
Fahraeus et al.
Oncogene, 1998;16:587
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