Catalog # Availability Size / Price Qty
Alsterpaullone | CAS No. 237430-03-4 | Cyclin-dependent Kinase Inhibitors
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Description: Potent cdk1 and cdk2 inhibitor; also inhibits GSK-3β and Lck

Chemical Name: 7,12-Dihydro-9-nitroindolo[3,2-d][1]benzazepin-6(5H)-one

Product Details

Biological Activity

Potent CDK1 and 2 inhibitor (IC50 values are 0.035 and 0.08 μM, respectively). Also inhibits GSK-3β and Lck (IC50 values are 0.11 and 0.47 μM, respectively). Induces apoptosis by activation of caspase-9; inhibits growth of cancer cell lines in vitro. Also glucocorticoid receptor inhibitor.

Technical Data

Soluble to 50 mM in DMSO
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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