Alsterpaullone

Key Product Details

Product Description

Alsterpaullone is a potent CDK1 and 2 inhibitor (IC₅₀ values are 0.035 and 0.08 μM, respectively). Also inhibits GSK-3β and Lck (IC₅₀ values are 0.11 and 0.47 μM, respectively). Induces apoptosis by activation of caspase-9; inhibits growth of cancer cell lines in vitro. Also glucocorticoid receptor inhibitor.

Product Specifications for Alsterpaullone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Alsterpaullone

The following data is based on the product molecular weight 293.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.82 mL	34.10 mL	68.19 mL
2.5 mM	1.36 mL	6.82 mL	13.64 mL
5 mM	0.68 mL	3.41 mL	6.82 mL
25 mM	0.14 mL	0.68 mL	1.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Jiang A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor. Sci.Rep. 2017 PMID: 28785063
• Bain The specificities of protein kinase inhibitors: an update. Biochem.J. 2003 PMID: 12534346
• Lahusen Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Mol.Carcinog. 2003 PMID: 12669310
• Schulz Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. J.Med.Chem. 1999 PMID: 10425100

Product Documents for Alsterpaullone