ALX 5407 hydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:1757
Alternate Names:(+)-NFPS
Chemical Name:N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).

Racemate also available.

Technical Data
  • M.Wt:
    429.92
  • Formula:
    C24H24FNO3.HCl
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    200006-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only
Other Product-Specific Information:
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
    Authors: Yue Et al.
    Nat.Commun.  2016;7:13501

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