ALX 5407 hydrochloride
Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Biological ActivityALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).
Racemate also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.
Atkinson et al.
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to cloz. in mouse models of schizophrenia.
Lipina et al.
Citation for ALX 5407 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:
1 Citation: Showing 1 - 1
Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
Authors: Yue Et al.
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