Catalog Number: 1757
Alternate Names: (+)-NFPS
Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Biological Activity
Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).
Technical Data
  • M.Wt:
    429.92
  • Formula:
    C24H24FNO3.HCl
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    200006-08-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only
Other Product-Specific Information:
Background References
  1. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.
    Atkinson et al.
    Mol.Pharmacol., 2001;60:1414
  2. Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
    Lipina et al.
    Psychopharmacology, 2005;179:54
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
    Authors: Yue Et al.
    Nat.Commun. 2016;7:13501

Have you used ALX 5407 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information