Selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50
values are 3 nM and > 100 μ
M for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50
> 100 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro
Other Product-Specific Information:
ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.
Atkinson et al.
Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display similar beneficial effects to clozapine in mouse models of schizophrenia.
Lipina et al.