ALX 5407 hydrochloride

Tocris Bioscience | Catalog # 1757

Selective non-transportable GlyT1 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective non-transportable GlyT1 inhibitor

Alternative Names

(+)-NFPS
View all Glycine Transporter Inhibitors »

Product Description

ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).

Racemate also available.

Licensing Information

Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only

Product Specifications for ALX 5407 hydrochloride

Molecular Weight

429.92

Formula

C24H24FNO3.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

CAS Number

200006-08-2

PubChem ID

16078946

InChI Key

RPDGSZCYSJWQEE-GNAFDRTKSA-N

SMILES

FC(C=C2)=CC=C2[C@@H](CCN(CC(O)=O)C)OC1=CC=C(C3=CC=CC=C3)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.99 100
Ethanol 21.5 50

Preparing Stock Solutions for ALX 5407 hydrochloride

The following data is based on the product molecular weight 429.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.63 mL 23.26 mL
5 mM 0.47 mL 2.33 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for ALX 5407 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ALX 5407 hydrochloride

For research use only

Citations for ALX 5407 hydrochloride

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