NFPS

  ( 2 citations )    
Product Datasheet
Catalog Number:2789
Alternate Names:(±)-NFPS
Chemical Name:N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
Product Details
Citations (2)
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Biological Activity
Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.

R-enantiomer also available.

Technical Data
  • M.Wt:
    393.45
  • Formula:
    C24H24FNO3
  • Solubility:
    Soluble to 10 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    405225-21-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for NFPS include:

2 Citations: Showing 1 - 2
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  1. Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission.
    Authors: Romei Et al.
    Brain Research Bulletin  2016;127:100
  2. Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
    Authors: DeBrouse Et al.
    Alcohol Clin Exp Res  2013;37:223

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