Catalog Number: 2789
Alternate Names: (±)-NFPS
Chemical Name: N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
Biological Activity
Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and� 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.
Technical Data
  • M.Wt:
    393.45
  • Formula:
    C24H24FNO3
  • Solubility:
    Soluble to 10 mM in DMSO and to 5 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    405225-21-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Modulation of N-methyl-D-aspartate receptor function by glycine transport.
    Bergeron et al.
    Proc.Natl.Acad.Sci.USA, 1998;95:15730
  2. Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
    Mallorga et al.
    Neuropharmacology, 2003;45:585
Citations:

The citations listed below are publications that use Tocris products. Selected citations for NFPS include:

1 Citations: Showing 1 - 1

  1. Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission.
    Authors: Romei Et al.
    Brain Research Bulletin 2016;127:100

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