Selective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50
values are 2.8, 9.8 and� 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Modulation of N-methyl-D-aspartate receptor function by glycine transport.
Bergeron et al.
Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
Mallorga et al.
The citations listed below are publications that use Tocris products. Selected citations for NFPS include:
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