Chemical Name: N-[3-([1,1-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine
Biological ActivitySelective, non-transportable inhibitor of GlyT1 which displays no activity at GABA or glutamate receptors (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Enhances the amplitude of the NMDA component of glutamatergic EPSCs.
R-enantiomer also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.
Mallorga et al.
Modulation of N-MthD.-aspartate receptor function by glycine transport.
Bergeron et al.
The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study.
Harsing Jr. et al.
Citations for NFPS
The citations listed below are publications that use Tocris products. Selected citations for NFPS include:
2 Citations: Showing 1 - 2
Colocalization of neurotransmitter transporters on the plasma membrane of the same nerve terminal may reflect cotransmission.
Authors: Romei Et al.
Brain Research Bulletin 2016;127:100
Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.
Authors: DeBrouse Et al.
Alcohol Clin Exp Res 2013;37:223
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