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AM 12

Catalog #: 6495 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6495/10
6495/50
AM 12 | TRPC Channel Blockers
1 Image
Description: TRPC5 inhibitor

Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one

Purity: ≥97%

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Biological Activity

AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.

Technical Data

M.Wt:
349.14
Formula:
C15H9BrO5
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Natural and synthetic flavonoid modulation of TRPC5 channels.
    Naylor et al.
    Br.J.Pharmacol., 2016;173:562

Product Datasheets

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