AM 12

Catalog # Availability Size / Price Qty
AM 12 | TRPC Channel Blockers
1 Image
Description: TRPC5 inhibitor

Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one

Purity: ≥97%

Product Details

Biological Activity

AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Natural and synthetic flavonoid modulation of TRPC5 channels.
    Naylor et al.
    Br.J.Pharmacol., 2016;173:562

Product Datasheets

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Reconstitution Calculator

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Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).


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