Catalog Number: 1370
Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol
Biological Activity
Endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.
Technical Data
  • M.Wt:
    379.48
  • Formula:
    C18H38NO5P
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    26993-30-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells.
    Essler et al.
    Cell.Signal., 2002;14:607
  2. Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
    Pyne and Pyne
    Pharmacol.Ther., 2000;88:115
  3. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
    Uhlenbrock et al.
    Cell.Signal., 2002;14:941
  4. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate.
    van Koppen et al.
    J.Biol.Chem., 1996;271:2082
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:

4 Citations: Showing 1 - 4
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  1. Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.
    Authors: Kho Et al.
    Mol Pain 2015;5:199
  2. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
    Authors: Evseenko Et al.
    PLoS One 2013;8:e63718
  3. Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
    Authors: Hannedouche Et al.
    Biosensors (Basel) 2013;288:27434
  4. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Authors: Pierre Et al.
    EMBO J 2004;23:3031

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