Endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+
mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5
) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.
Desiccate at +4°C
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Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells.
Essler et al.
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
Pyne and Pyne
Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Uhlenbrock et al.
Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate.
van Koppen et al.
The citations listed below are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:
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