Sphingosine-1-phosphate

Key Product Details

Product Description

Sphingosine-1-phosphate is an endogenous second messenger involved in the control of cell proliferation and motility, and Ca²⁺ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P_1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2'3'-cyclic-GMP-AMP (cGAMP).

Product Specifications for Sphingosine-1-phosphate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 52 publications citing the usage of this product.

• Lahey LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP. Mol.Cell. 2020 PMID: 33171122
• Morstein Optical control of sphingosine-1-phosphate formation and function. Nat.Chem 2019 PMID: 31036923
• van Koppen Activation of a high affinity G_i protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J.Biol.Chem. 1996 PMID: 8567663
• Uhlenbrock Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell.Signal. 2002 PMID: 12220620
• Pyne and Pyne Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. Pharmacol.Ther. 2000 PMID: 11150592
• Essler Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells. Cell.Signal. 2002 PMID: 11955953

Product Documents for Sphingosine-1-phosphate