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Sphingosine-1-phosphate | CAS No. 26993-30-6 | Sphingosine-1-phosphate Receptor Agonists
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Description: Endogenous agonist at S1P1-5

Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol

Purity: ≥98%

Product Details
Citations (10)
Supplemental Products

Biological Activity

Sphingosine-1-phosphate is an endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2'3'-cyclic-GMP-AMP (cGAMP).

Technical Data

Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Sphingosine-1-phosphate

The citations listed below are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:

10 Citations: Showing 1 - 10

  1. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
    Authors: H?bner Et al.
    Nat Commun  2018;9:4860
  2. The signaling lipid sphingosine 1-phosphate regulates mechanical pain.
    Authors: Hill Et al.
    Elife  2018;7
  3. Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
    Authors: Krispin Et al.
    Arterioscler Thromb Vasc Biol  2018;38:353
  4. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
    Authors: Simula Et al.
    Cell Rep  2018;25:3059
  5. Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development.
    Authors: Hu Et al.
    J Am Soc Nephrol  2016;27:1984
  6. Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
    Authors: Camp Et al.
    Pharmacol Res  2016;105:13
  7. Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.
    Authors: Kho Et al.
    Mol Pain  2015;5:199
  8. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
    Authors: Evseenko Et al.
    PLoS One  2013;8:e63718
  9. Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
    Authors: Hannedouche Et al.
    Biosensors (Basel)  2013;288:27434
  10. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Authors: Pierre Et al.
    EMBO J  2004;23:3031


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