Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol
Biological ActivityEndogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase. Also activates VRAC-mediated transport of 2'3'-cyclic-GMP-AMP (cGAMP).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells.
Essler et al.
Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors.
Pyne and Pyne
Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.
Uhlenbrock et al.
Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate.
van Koppen et al.
Optical control of sphingosine-1-phosphate formation and function.
Morstein et al.
LRRC8A:C/E heteromeric channels are ubiquitous transporters of cGAMP.
Lahey et al.
Citations for Sphingosine-1-phosphate
The citations listed below are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:
10 Citations: Showing 1 - 10
Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
Authors: H?bner Et al.
Nat Commun 2018;9:4860
The signaling lipid sphingosine 1-phosphate regulates mechanical pain.
Authors: Hill Et al.
Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
Authors: Krispin Et al.
Arterioscler Thromb Vasc Biol 2018;38:353
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Authors: Simula Et al.
Cell Rep 2018;25:3059
Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development.
Authors: Hu Et al.
J Am Soc Nephrol 2016;27:1984
Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
Authors: Camp Et al.
Pharmacol Res 2016;105:13
Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.
Authors: Kho Et al.
Mol Pain 2015;5:199
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
Authors: Evseenko Et al.
PLoS One 2013;8:e63718
Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
Authors: Hannedouche Et al.
Biosensors (Basel) 2013;288:27434
PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
Authors: Pierre Et al.
EMBO J 2004;23:3031
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