Sphingosine-1-phosphate

Catalog # Availability Size / Price Qty
1370/1
Sphingosine-1-phosphate | CAS No. 26993-30-6 | Sphingosine-1-phosphate Receptor Agonists
1 Image
Description: Endogenous agonist at S1P1-5

Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol

Purity: ≥98%

Product Details
Citations (10)
Supplemental Products
Reviews

Biological Activity

Endogenous second messenger involved in the control of cell proliferation and motility, and Ca2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Technical Data

M.Wt:
379.48
Formula:
C18H38NO5P
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
26993-30-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Sphingosine-1-phosphate

The citations listed below are publications that use Tocris products. Selected citations for Sphingosine-1-phosphate include:

10 Citations: Showing 1 - 10

  1. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.
    Authors: H?bner Et al.
    Nat Commun  2018;9:4860
  2. The signaling lipid sphingosine 1-phosphate regulates mechanical pain.
    Authors: Hill Et al.
    Elife  2018;7
  3. Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling.
    Authors: Krispin Et al.
    Arterioscler Thromb Vasc Biol  2018;38:353
  4. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
    Authors: Simula Et al.
    Cell Rep  2018;25:3059
  5. Hemovascular Progenitors in the Kidney Require Sphingosine-1-Phosphate Receptor 1 for Vascular Development.
    Authors: Hu Et al.
    J Am Soc Nephrol  2016;27:1984
  6. Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics.
    Authors: Camp Et al.
    Pharmacol Res  2016;105:13
  7. Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.
    Authors: Kho Et al.
    Mol Pain  2015;5:199
  8. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment.
    Authors: Evseenko Et al.
    PLoS One  2013;8:e63718
  9. Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells.
    Authors: Hannedouche Et al.
    Biosensors (Basel)  2013;288:27434
  10. PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate.
    Authors: Pierre Et al.
    EMBO J  2004;23:3031

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Sphingosine-1-phosphate

There are currently no reviews for this product. Be the first to review Sphingosine-1-phosphate and earn rewards!

Have you used Sphingosine-1-phosphate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.