Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Biological ActivityHigh affinity and selective CB1 antagonist (Kd = 0.89 nM). Exhibits 100-fold selectivity for CB1 over CB2. Attenuates CB1 agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
Sink et al.
The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats
Hodge et al.
Behav. Brain Res., 2008;193:298
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