Catalog Number: 6193
Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Biological Activity
High affinity and selective CB1 antagonist (Kd = 0.89 nM). Exhibits 100-fold selectivity for CB1 over CB2. Attenuates CB1 agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.
Technical Data
  • M.Wt:
    380.66
  • Formula:
    C17H12Cl3N3O
  • Solubility:
    Soluble to 20 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    614726-85-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
    Sink et al.
    Neuropsychopharmacology, 2008;33:946
  2. The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats
    Hodge et al.
    Behav. Brain Res., 2008;193:298
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