Catalog Number: 0760
Chemical Name: 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid
Biological Activity
An analog of retinoic acid that acts as a selective RARα agonist (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFNγ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
    Kagechika et al.
    J.Med.Chem., 1988;31:2182
  2. Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives.
    Charton et al.
    Bioorg.Med.Chem.Lett., 2009;19:489
  3. The retinoic acid receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production.
    Dawson et al.
    BMC Immunol., 2008;9:16
  4. Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
    Wang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2011;108:18283
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