AM 580

  ( 11 citations )    
Product Datasheet
Catalog Number:0760
Chemical Name:4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid
Product Details
Citations (11)
Reviews
Biological Activity
An analog of retinoic acid that acts as a selective RARα agonist (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFNγ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro.
Technical Data
  • M.Wt:
    351.44
  • Formula:
    C22H25NO3
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    102121-60-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AM 580 include:

11 Citations: Showing 1 - 10
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  1. Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells.
    Authors: Kelley
    PLoS One  2017;12(5):e0178116
  2. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
    Authors: Chronopoulos Et al.
    Nature Communications  2016;7:12630
  3. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
    Authors: Centritto Et al.
    Cell Death Dis  2015;7:950
  4. Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.
    Authors: Brigger Et al.
    Mucosal Immunol  2015;6:e1861
  5. BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
    Authors: Perri Et al.
    Exp Cell Res  2014;327:183
  6. Macrophages engulfing apoptotic cells produce nonclassical retinoids to enhance their phagocytic capacity.
    Authors: Sarang Et al.
    J Immunol  2014;192:5730
  7. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun  2013;4:2175
  8. Increased dietary intake of vitamin A promotes aortic valve calcification in vivo.
    Authors: Huk Et al.
    Arterioscler Thromb Vasc Biol  2013;33:285
  9. Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.
    Authors: Kang Et al.
    Dev Biol  2011;4:66
  10. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
    Authors: DePaolo Et al.
    Nature  2011;471:220
  11. Zebrafish nephrogenesis involves dynamic spatiotemporal expression changes in renal progenitors and essential signals from retinoic acid and irx3b.
    Authors: Wingert and Davidson
    Dev Dyn  2011;240:2011
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