Catalog Number: 2404
Chemical Name: trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride
Biological Activity
Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Technical Data
  • M.Wt:
    414.57
  • Formula:
    C13H18Br2N2O.HCl
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    23828-92-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
    Gibbs et al.
    Inflamm.Res., 1999;48:86
  2. Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol.
    Weiser and Wilson
    Mol.Pharmacol., 2002;62:433
  3. Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro.
    Gillissen et al.
    Lung, 1997;175:235

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