Ambroxol hydrochloride

Key Product Details

Product Description

Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC₅₀ values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus.

Product Specifications for Ambroxol hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ambroxol hydrochloride

The following data is based on the product molecular weight 414.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.82 mL	24.12 mL	48.24 mL
2.5 mM	0.96 mL	4.82 mL	9.65 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
25 mM	0.10 mL	0.48 mL	0.96 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Yang Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur.Respir.J. 2002 PMID: 12030738
• Gibbs Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 1999 PMID: 10202994
• Weiser and Wilson Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na⁺ channels by the secretolytic ambroxol. Mol.Pharmacol. 2002 PMID: 12181417
• Gillissen Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 1997 PMID: 9195551

Product Documents for Ambroxol hydrochloride