Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50
values for tonic block are 35.2 and 111.5 μ
M respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Soluble to 50 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Gibbs et al.
Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol.
Weiser and Wilson
Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro.
Gillissen et al.