Chemical Name: trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride
Biological ActivitySodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro.
Gillissen et al.
Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.
Gibbs et al.
Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol.
Weiser and Wilson
Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels.
Yang et al.
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