AMG 510

Key Product Details

Product Description

AMG 510 is a potent and selective covalent KRAS^G12C inhibitor (IC₅₀ = 90 nM). Also a potent inhibitor of phospho-ERK (IC₅₀ = 68 nM). In an in vivo model of non-small cell lung cancer, AMG 510 causes regression of tumors, an increase in T-cell recruitment and a pro-inflammatory tumor microenvironment. Synergises with MEK inhibitors and Carboplatin (Cat. No. 2626) and is orally bioavailable.

Product Specifications for AMG 510

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AMG 510

The following data is based on the product molecular weight 560.60.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL
10 mM	0.18 mL	0.89 mL	1.78 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Canon The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature 2019 PMID: 31666701
• Lanman Discovery of a covalent inhibitor of KRAS^G12C (AMG 510) for the treatment of solid tumors. J.Med.Chem. 2020 PMID: 31820981

Product Documents for AMG 510