Catalog Number: 3920
Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
Biological Activity
Potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.
Technical Data
  • M.Wt:
    461.56
  • Formula:
    C29H27N5O
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    864249-60-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein.
    Lee and Dominguez
    Curr.Med.Chem., 2005;12:2979
  2. p38 MAP kinase inhibitors: many are made, but few are chosen.
    Dominguez et al.
    Curr.Opin.Drug Discov.Devel., 2005;8:421
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMG 548 include:

1 Citations: Showing 1 - 1

  1. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
    Authors: Eckle Et al.
    J Biol Chem 2013;11:e1001665

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