Potent and selective inhibitor of p38α
values are 0.5, 3.6, 2600 and 4100 nM for p38α
respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα
= 3 nM)
. Efficacious in acute and chronic models of arthritis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein.
Lee and Dominguez
p38 MAP kinase inhibitors: many are made, but few are chosen.
Dominguez et al.
Curr.Opin.Drug Discov.Devel., 2005;8:421
The citations listed below are publications that use Tocris products. Selected citations for AMG 548 include:
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