AMG 548

Catalog # Availability Size / Price Qty
3920/10
Cat.No. 3920 - AMG 548 | C29H27N5O | CAS No. 864249-60-5
1 Image
Description: Potent and selective p38α inhibitor

Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.

Technical Data

M.Wt:
461.56
Formula:
C29H27N5O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
864249-60-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. p38 MAP kinase inhibitors: many are made, but few are chosen.
    Dominguez et al.
    Curr.Opin.Drug Discov.Devel., 2005;8:421
  2. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein.
    Lee and Dominguez
    Curr.Med.Chem., 2005;12:2979

Product Datasheets

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Citation for AMG 548

The citations listed below are publications that use Tocris products. Selected citations for AMG 548 include:

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