Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
Biological ActivityAMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
p38 MAP kinase inhibitors: many are made, but few are chosen.
Dominguez et al.
Curr.Opin.Drug Discov.Devel., 2005;8:421
MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein.
Lee and Dominguez
Citation for AMG 548
The citations listed below are publications that use Tocris products. Selected citations for AMG 548 include:
1 Citation: Showing 1 - 1
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Authors: Eckle Et al.
J Biol Chem 2013;11:e1001665
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