AMG 837 hemicalcium salt

Key Product Details

Product Description

AMG 837 hemicalcium salt is a potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist (EC₅₀ values are 13.5, 22.6 and 31.7 nM at human, mouse and rat receptors, respectively). Interacts allosterically with full FFA1 agonist Docosahexaenoic acid (Cat. No. 3687). Potentiates glucose-dependent stimulation of insulin in vivo. Antidiabetic.

Product Specifications for AMG 837 hemicalcium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AMG 837 hemicalcium salt

The following data is based on the product molecular weight 457.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.93 mL	21.86 mL
5 mM	0.44 mL	2.19 mL	4.37 mL
10 mM	0.22 mL	1.09 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lin Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol.Pharmacol. 2012 PMID: 22859723
• Lin AMG 837: a novel GPR40/FFA1 agonist that enhances Ins secretion and lowers glucose levels in rodents. PLoS One 2011 PMID: 22087278
• Houze AMG 837: a potent, orally bioavailable GPR40 agonist. Bioorg.Med.Chem.Lett. 2012 PMID: 22217876

Product Documents for AMG 837 hemicalcium salt