Aminoguanidine hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Suppression of Canine Dendritic Cell Activation/Maturation and Inflammatory Cytokine Release by Mesenchymal Stem Cells Occurs Via Multiple Distinct Biochemical Pathways
   
   Stem Cells Dev., 2016;0(0):.
3. Aminoguanidine selectively inhibits inducible nitric oxide synthase.
   Griffiths et al.
   Br.J.Pharmacol., 1993;110:963
4. Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect.
   Huang et al.
   Int.J.Radiat.Oncol.Biol.Phys., 2009;74:237
5. Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo.
   Laszlo et al.
   Eur.J.Pharmacol., 1995;272:169
6. Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system?
   Moore and Handy
   TiPS, 1997;18:204

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