Chemical Name: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Biological ActivityAminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 >100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
Chang et al.
Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
Knockaert et al.
How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
Jorda et al.
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts.
Rosiana et al.
Citation for Aminopurvalanol A
The citations listed below are publications that use Tocris products. Selected citations for Aminopurvalanol A include:
1 Citation: Showing 1 - 1
An evolutionary conserved role of Wnt signaling in stem cell fate decision.
Authors: Teo Et al.
Dev Biol 2006;289:91
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