Aminopurvalanol A

Catalog # Availability Size / Price Qty
2072/10
2072/50
Aminopurvalanol A | CAS No. 220792-57-4 | Cyclin-dependent Kinase Inhibitors
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Description: Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names: NG 97

Chemical Name: (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC50 >100 μM). Arrests cell cycle at G2/M boundary (IC50 = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

Technical Data

M.Wt:
403.91
Formula:
C19H26ClN7O
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
220792-57-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Regents of the University of California

Background References

  1. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
    Chang et al.
    Chem.Biol., 1999;6:361
  2. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.
    Knockaert et al.
    Chem.Biol., 2000;7:411
  3. How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases?
    Jorda et al.
    J.Med.Chem., 2018;61:9105
  4. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts.
    Rosiana et al.
    Proc.Natl.Acad.Sci.USA, 1999;96:4797

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Citation for Aminopurvalanol A

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