Aminopurvalanol A

Key Product Details

Product Description

Aminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC₅₀ = 12.0 μM) and ERK2 (IC₅₀ = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC₅₀ >100 μM). Arrests cell cycle at G2/M boundary (IC₅₀ = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

Licensing Information

Sold under license from the Regents of the University of California

Product Specifications for Aminopurvalanol A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Aminopurvalanol A

The following data is based on the product molecular weight 403.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.38 mL	24.76 mL
5 mM	0.50 mL	2.48 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
• Knockaert Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 2000 PMID: 10873834
• Rosiana A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA
• Chang Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 1999 PMID: 10375538

Product Documents for Aminopurvalanol A