Amlodipine besylate

Tocris Bioscience | Catalog # 2571

CaV1.x blocker
Tocris Bioscience

Key Product Details

Description

CaV1.x blocker

Alternative Names

Norvasc
View all Cav1.x Channel Blockers »

Product Description

Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

Product Specifications for Amlodipine besylate

Molecular Weight

567.05

Formula

C20H25ClN2O5.C6H6O3S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

CAS Number

111470-99-6

PubChem ID

60496

InChI Key

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

SMILES

OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.7 100

Preparing Stock Solutions for Amlodipine besylate

The following data is based on the product molecular weight 567.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.82 mL 17.64 mL
5 mM 0.35 mL 1.76 mL 3.53 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Product Documents for Amlodipine besylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Amlodipine besylate

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Amlodipine besylate

Customer Reviews for Amlodipine besylate (1)

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  • Amlodipin blocks cardiac calcium current
    Name: Chintan Koyani
    Species: Guinea Pig
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/23/2018
    L-type Ca2+ current was analysed by patch clamp in guinea pig ventricular cardiomyocytes before and after amlodipine (10 µM) superfusion. Amlodipine blocked calcium current density.
    Amlodipine besylate 2571

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