Amlodipine besylate

  ( 2 citations )    
Product Datasheet
Catalog Number:2571
Alternate Names:Norvasc
Chemical Name:2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
Product Details
Citations (2)
Reviews
Biological Activity
L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).
Technical Data
  • M.Wt:
    567.05
  • Formula:
    C20H25ClN2O5.C6H6O3S
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    111470-99-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amlodipine besylate include:

2 Citations: Showing 1 - 2
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  1. Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
    Authors: Sharma Et al.
    PLoS One  2016;11:e0163845
  2. Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva).
    Authors: Zhong Et al.
    PLoS One  2014;9:e104718

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