L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+
-induced contractions in depolarized rat aorta (IC50
= 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50
= 25 μ
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All Tocris products are intended for laboratory research use only.
Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors.
Burges et al.
Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells.
Yoshida et al.
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hype
Toba et al.