Amlodipine besylate

Catalog # Availability Size / Price Qty
2571/50
Amlodipine besylate | CAS No. 111470-99-6 | Cav1.x Channel Blockers
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Description: CaV1.x blocker
Alternative Names: Norvasc

Chemical Name: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

Purity: ≥99%

Product Details
Citations (2)
Reviews (1)

Biological Activity

L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).

Technical Data

M.Wt:
567.05
Formula:
C20H25ClN2O5.C6H6O3S
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
111470-99-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Amlodipine besylate

The citations listed below are publications that use Tocris products. Selected citations for Amlodipine besylate include:

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Amlodipin blocks cardiac calcium current
By Chintan Koyani on 10/23/2018
Species: Other

L-type Ca2+ current was analysed by patch clamp in guinea pig ventricular cardiomyocytes before and after amlodipine (10 µM) superfusion. Amlodipine blocked calcium current density.


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