AMN 082 dihydrochloride

Catalog # Availability Size / Price Qty
2385/10
2385/50
Cat.No. 2385 - AMN 082 dihydrochloride | C28H28N2.2HCl | CAS No. 97075-46-2
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Description: Selective mGlu7 agonist

Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

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Technical Data

M.Wt:
465.45
Formula:
C28H28N2.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 2 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
97075-46-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
    Greco et al.
    J.Pharmacol.Exp.Ther., 2010;332:1064
  2. AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo.
    Flor et al.
    Neuropharmacology, 2005;49:244
  3. A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
    Mitsukawa et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:18712

Product Datasheets

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Citation for AMN 082 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:

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