AMN 082 dihydrochloride
Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride
Biological ActivityAMN 082 dihydrochloride is a the first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.
View important information regarding the usage of AMN 082 dihydrochloride.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Greco et al.
AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo.
Flor et al.
A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Mitsukawa et al.
Citations for AMN 082 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:
3 Citations: Showing 1 - 3
Activating metabotropic glutamate receptor-7 attenuates visceral hypersensitivity in neonatal maternally separated rats.
Authors: Shao Et al.
Int J Mol Med 2019;43:761
New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection.
Authors: Jantas Et al.
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
Authors: Broadstock Et al.
Br J Pharmacol 2012;165:1034
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for AMN 082 dihydrochloride
There are currently no reviews for this product. Be the first to review AMN 082 dihydrochloride and earn rewards!
Have you used AMN 082 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image