AMN 082 dihydrochloride
Chemical Name: N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride
Biological ActivityThe first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Greco et al.
AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo.
Flor et al.
A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Mitsukawa et al.
Citations for AMN 082 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:
3 Citations: Showing 1 - 3
Activating metabotropic glutamate receptor-7 attenuates visceral hypersensitivity in neonatal maternally separated rats.
Authors: Shao Et al.
Int J Mol Med 2019;43:761
New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection.
Authors: Jantas Et al.
Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
Authors: Broadstock Et al.
Br J Pharmacol 2012;165:1034
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