AMN 082 dihydrochloride

  ( 1 citations )    
Product Datasheet
Catalog Number:2385
Chemical Name:N,N'-Bis(diphenylmethyl)-1,2-ethanediamine dihydrochloride
Product Details
Citations (1)
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Biological Activity
The first selective mGlu7 agonist. Potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μM. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.

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Technical Data
  • M.Wt:
    465.45
  • Formula:
    C28H28N2.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 2 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    97075-46-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:

1 Citations: Showing 1 - 1

  1. Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata.
    Authors: Broadstock Et al.
    Br J Pharmacol  2012;165:1034

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VersaClone cDNA Plasmids
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Human mGluR7 (NP_000835) VersaClone cDNA

RDC1001
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