The first selective mGlu7
agonist. Potently inhibits cAMP accumulation and stimulates GTPγ
S binding in recombinant cells and on membranes expressing mGlu7
= 64 - 290 nM). Selective over other mGluR subtypes and selected ionotropic glutamate receptors up to 10 μ
M. Acts via a novel allosteric site and is orally active and brain penetrant. Reduces haloperidol-induced catalepsy in rats.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease.
Greco et al.
AMN082, the first selective mGluR7 agonist: activation of receptor signaling via an allosteric site in the transmembrane domain modulates stress parameters in vivo.
Flor et al.
The citations listed below are publications that use Tocris products. Selected citations for AMN 082 dihydrochloride include:
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