Catalog Number: 0871
Chemical Name: 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine hydrochloride
Biological Activity
Potent, selective and reversible inhibitor of iNOS (IC50 = 3.6 nM; approximately 30 and 40 times selective over nNOS and eNOS respectively).
Technical Data
  • M.Wt:
    166.67
  • Formula:
    C5H10N2S.HCl
  • Solubility:
    Soluble to 10 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
    21463-31-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes.
    Liao et al.
    FASEB J., 2006;20:E1196
  2. Novel potent and selective inhibitors of inducible nitric oxide synthase.
    Nakane et al.
    Mol.Pharmacol., 1995;47:831
  3. Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes.
    Yu et al.
    J.Physiol., 2005;566:327
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AMT hydrochloride include:

3 Citations: Showing 1 - 3
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  1. Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents.
    Authors: Lee Et al.
    PLoS One 2016;24:67
  2. Involvement of nitric oxide in the modulation of dural arterial blood flow in the rat.
    Authors: Messlinger Et al.
    Br J Pharmacol 2000;129:1397
  3. Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils.
    Authors: Zanardo Et al.
    Proc Natl Acad Sci U S A 1997;94:14111

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