Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine
Biological ActivityAdenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug.
Pinna et al.
Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
Volpini et al.
Citation for ANR 94
The citations listed below are publications that use Tocris products. Selected citations for ANR 94 include:
1 Citation: Showing 1 - 1
Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
Authors: Schneider Et al.
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VersaClone cDNA Plasmids
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