Catalog Number: 3937
Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine
Biological Activity
Adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.
Technical Data
  • M.Wt:
    207.23
  • Formula:
    C9H13N5O
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    634924-89-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug.
    Pinna et al.
    Neuropharmacology, 2010;58:613
  2. Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
    Volpini et al.
    Chem.Med.Chem., 2010;4:1010
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ANR 94 include:

1 Citations: Showing 1 - 1

  1. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.
    Authors: Schneider Et al.
    Circulation 2015;14:201

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