ANR 94

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3937/10
3937/50
ANR 94 | CAS No. 634924-89-3 | Adenosine A2a Receptor Antagonists
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Description: Adenosine A2A antagonist

Chemical Name: 8-Ethoxy-9-ethyl-9H-purin-6-amine

Purity: ≥99%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

Adenosine A2A receptor (AA2AR) antagonist (Ki values are 643 and 46 nM for rat and human AA2ARs respectively). Most active AA2AR antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.

Technical Data

M.Wt:
207.23
Formula:
C9H13N5O
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
634924-89-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug.
    Pinna et al.
    Neuropharmacology, 2010;58:613
  2. Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
    Volpini et al.
    Chem.Med.Chem., 2010;4:1010

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Citation for ANR 94

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