R) antagonist (Ki
values are 643 and 46 nM for rat and human AA2A
Rs respectively). Most active AA2A
R antagonist for human receptors. Displays activity in the treatment of Parkinson's disease in vivo
; improves parkinsonian motor deficits and tremors. Exhibits neuroprotective and anti-inflammatory effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A new ethyladenine antagonist of adenosine A2A receptors: Behavioral and biochemical characterization as an antiparkinsonian drug.
Pinna et al.
Adenosine A2A receptor antagonists: New 8-substituted 9-ethyladenines as tools for in vivo rat models of Parkinson's disease.
Volpini et al.
The citations listed below are publications that use Tocris products. Selected citations for ANR 94 include:
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