Antalarmin hydrochloride

  ( 4 citations )    
Product Datasheet
Catalog Number:2778
Chemical Name:N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
Technical Data
  • M.Wt:
    415.01
  • Formula:
    C24H34N4.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    220953-69-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Antalarmin hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors.
    Authors: Narla Et al.
    Psychoneuroendocrinology  2015;9:200
  2. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
    Authors: Zhao-Shea Et al.
    Front Cell Neurosci  2015;6:6770
  3. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
    Authors: Gray Et al.
    J Neurosci  2015;35:3879
  4. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
    Authors: Wood Et al.
    Neuropsychopharmacology  2006;31:2580

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