Catalog Number: 2778
Chemical Name: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Biological Activity
Non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
Technical Data
  • M.Wt:
    415.01
  • Formula:
    C24H34N4.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    220953-69-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.
    Webster et al.
    Endocrinology, 1996;137:5747
  2. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
    Zorrilla et al.
    Brain Res., 2002;952:188
  3. CRF1 receptor antagonists attenuate ascalated cocaine self-administration in rats.
    Specio et al.
    Psychopharmacol., 2008;196:473
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Antalarmin hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors.
    Authors: Narla Et al.
    Psychoneuroendocrinology 2015;9:200
  2. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
    Authors: Zhao-Shea Et al.
    Front Cell Neurosci 2015;6:6770
  3. Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
    Authors: Gray Et al.
    J Neurosci 2015;35:3879
  4. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
    Authors: Wood Et al.
    Neuropsychopharmacology 2006;31:2580

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