Chemical Name: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Biological ActivityNon-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.
Webster et al.
Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
Zorrilla et al.
Brain Res., 2002;952:188
CRF1 receptor antagonists attenuate ascalated cocaine self-administration in rats.
Specio et al.
Citations for Antalarmin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Antalarmin hydrochloride include:
4 Citations: Showing 1 - 4
Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors.
Authors: Narla Et al.
Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal.
Authors: Zhao-Shea Et al.
Front Cell Neurosci 2015;6:6770
Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety.
Authors: Gray Et al.
J Neurosci 2015;35:3879
Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
Authors: Wood Et al.
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