Antalarmin hydrochloride

Catalog # Availability Size / Price Qty
2778/10
2778/50
Antalarmin hydrochloride | CAS No. 220953-69-5 | CRF1 Receptor Antagonists
1 Image
Description: CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews

Biological Activity

Non-peptide corticotropin-releasing hormone receptor 1 (CRF1) antagonist (Ki = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Technical Data

M.Wt:
415.01
Formula:
C24H34N4.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
220953-69-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.
    Webster et al.
    Endocrinology, 1996;137:5747
  2. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
    Zorrilla et al.
    Brain Res., 2002;952:188
  3. CRF1 receptor antagonists attenuate ascalated cocaine self-administration in rats.
    Specio et al.
    Psychopharmacol., 2008;196:473

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Antalarmin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Antalarmin hydrochloride include:

4 Citations: Showing 1 - 4

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Antalarmin hydrochloride

There are currently no reviews for this product. Be the first to review Antalarmin hydrochloride and earn rewards!

Have you used Antalarmin hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.