Non-peptide corticotropin-releasing hormone receptor 1 (CRF1
) antagonist (Ki
= 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
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All Tocris products are intended for laboratory research use only.
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation.
Webster et al.
Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat.
Zorrilla et al.
Brain Res., 2002;952:188
CRF1 receptor antagonists attenuate ascalated cocaine self-administration in rats.
Specio et al.
The citations listed below are publications that use Tocris products. Selected citations for Antalarmin hydrochloride include:
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