Biological Activity Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Store at RT
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For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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