Catalog Number: 2151
Alternate Names: Triciribine, NSC 154020, TCN
Chemical Name: 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Biological Activity
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Technical Data
  • M.Wt:
    320.31
  • Formula:
    C13H16N6O4
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    35943-35-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dual mechanisms of inhibition of DNA synthesis by triciribine.
    Wotring et al.
    Cancer Res., 1990;50:4891
  2. Phosphorylation of triciribine is necessary for activity against HIV type 1.
    Ptak et al.
    AIDS Res.Hum.Retroviruses., 1998;14:1315
  3. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumour activity in cancer cells overexpressing Akt.
    Yang et al.
    Cancer Res., 2004;64:4394
Citations:

The citations listed below are publications that use Tocris products. Selected citations for API-2 include:

11 Citations: Showing 1 - 10
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  1. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
    Authors: Rosenberg Et al.
    Biol Open 2015;8:42614
  2. Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.
    Authors: Kuo Et al.
    J Lipid Res 2014;55:919
  3. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
    Authors: Shravah Et al.
    Am J Physiol Renal Physiol 2014;3:e29554
  4. Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division.
    Authors: Robertson Et al.
    Blood 2013;2:472
  5. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem 2012;287:3963
  6. mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
    Authors: Duan Et al.
    JAKSTAT 2011;44:317
  7. NKG2D receptor regulates human effector T-cell cytokine production.
    Authors: Barber and Sentman
    Mol Cell 2011;117:6571
  8. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One 2010;5:e11962
  9. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model.
    Authors: Liu Et al.
    Am J Physiol Endocrinol Metab 2010;299:E351
  10. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Authors: Sunters Et al.
    J Biol Chem 2010;285:8743
  11. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One 2009;4:e6011
Expand to show all 11 Citations

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