Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β
and AFX. Induces apoptosis and growth arrest in vitro
, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Dual mechanisms of inhibition of DNA synthesis by triciribine.
Wotring et al.
Cancer Res., 1990;50:4891
Phosphorylation of triciribine is necessary for activity against HIV type 1.
Ptak et al.
AIDS Res.Hum.Retroviruses., 1998;14:1315
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumour activity in cancer cells overexpressing Akt.
Yang et al.
Cancer Res., 2004;64:4394
The citations listed below are publications that use Tocris products. Selected citations for API-2 include:
Showing Results 1 - 10 of 11