API-2

  ( 14 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2151
Alternate Names:Triciribine, NSC 154020, TCN
Chemical Name:1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
Technical Data
  • M.Wt:
    320.31
  • Formula:
    C13H16N6O4
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    35943-35-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for API-2 include:

14 Citations: Showing 1 - 10
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  1. Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.
    Authors: Arqu&eacutes Et al.
    Clin Cancer Res  2016;22:644
  2. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
    Authors: Rosenberg Et al.
    Biol Open  2015;8:42614
  3. PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.
    Authors: Kana Et al.
    Tissue Eng Part A  2015;21:2379
  4. Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.
    Authors: Kuo Et al.
    J Lipid Res  2014;55:919
  5. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
    Authors: Shravah Et al.
    Am J Physiol Renal Physiol  2014;3:e29554
  6. Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division.
    Authors: Robertson Et al.
    Blood  2013;2:472
  7. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
    Authors: Woo Et al.
    J Biol Chem  2012;287:3963
  8. mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
    Authors: Duan Et al.
    JAKSTAT  2011;44:317
  9. NKG2D receptor regulates human effector T-cell cytokine production.
    Authors: Barber and Sentman
    Mol Cell  2011;117:6571
  10. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
    Authors: Jackson Et al.
    PLoS One  2010;5:e11962
  11. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model.
    Authors: Liu Et al.
    Am J Physiol Endocrinol Metab  2010;299:E351
  12. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Authors: Sunters Et al.
    J Biol Chem  2010;285:8743
  13. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  14. PRAS40 deregulates apoptosis in malignant melanoma.
    Authors: Madhunapantula Et al.
    Cancer Res  2007;67:3626
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Average Rating: 5 (Based on 1 review)

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  Mouse Zhenmin Lei 01/04/2018
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Species Mouse
Pub Med ID PMID: 28137614

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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