Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Biological ActivityHigh affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug.
Doods et al.
Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
Dorje et al.
Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle.
Doods et al.
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