AQ-RA 741

Key Product Details

Product Description

AQ-RA 741 is a high affinity, selective muscarinic M₂ receptor antagonist (pK_i values are 8.3, 7.7 and 6.82 for M₂, M₁ and M₃ receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.

Product Specifications for AQ-RA 741

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AQ-RA 741

The following data is based on the product molecular weight 463.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.16 mL	10.78 mL	21.57 mL
5 mM	0.43 mL	2.16 mL	4.31 mL
10 mM	0.22 mL	1.08 mL	2.16 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Dorje Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J.Pharmacol.Exp.Ther. 1991 PMID: 1994002
• Doods Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 1994 PMID: 8200421
• Doods Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug. Eur.J.Pharmacol. 1991 PMID: 2040358

Product Documents for AQ-RA 741