Catalog Number: 2292
Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Biological Activity
High affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug.
    Doods et al.
    Eur.J.Pharmacol., 1991;192:147
  2. Antagonist binding profiles of five cloned human muscarinic receptor subtypes.
    Dorje et al.
    J.Pharmacol.Exp.Ther., 1991;256:727
  3. Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle.
    Doods et al.
    Eur.J.Pharmacol., 1994;253:275
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