Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50
= 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50
values are > 100 μ
M) and over 26 other kinases. Inhibits β
-amyloid-mediated neurodegeneration in hippocampal slices.
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Sold with the permission of AstraZeneca UK Ltd.
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Bhat et al.
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
Gould et al.
GSK3β signalling: casting a wide net in Alzheimer's disease.
Bhat and Budd
The citations listed below are publications that use Tocris products. Selected citations for AR-A 014418 include:
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