Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Biological ActivityAR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
GSK3β signalling: casting a wide net in Alzheimer's disease.
Bhat and Budd
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Bhat et al.
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
Gould et al.
Citations for AR-A 014418
The citations listed below are publications that use Tocris products. Selected citations for AR-A 014418 include:
3 Citations: Showing 1 - 3
GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
Authors: Penas Et al.
Tuberc Respir Dis (Seoul) 2015;14:417
GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
Authors: Cuesto Et al.
PLoS One 2015;10:e0118475
Spatially coordinated kinase signaling regulates local axon degeneration.
Authors: Chen Et al.
J Neurosci 2012;32:13439
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