AR-A 014418

  ( 3 citations )    
Product Datasheet
Catalog Number:3966
Chemical Name:N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Product Details
Citations (3)
Reviews
Biological Activity
Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Technical Data
  • M.Wt:
    308.31
  • Formula:
    C12H12N4O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    487021-52-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AR-A 014418 include:

3 Citations: Showing 1 - 3
Filter your results:

  1. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
    Authors: Penas Et al.
    Tuberc Respir Dis (Seoul)  2015;14:417
  2. GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
    Authors: Cuesto Et al.
    PLoS One  2015;10:e0118475
  3. Spatially coordinated kinase signaling regulates local axon degeneration.
    Authors: Chen Et al.
    J Neurosci  2012;32:13439

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used AR-A 014418?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee