Catalog Number: 3966
Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Biological Activity
Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Technical Data
  • M.Wt:
    308.31
  • Formula:
    C12H12N4O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    487021-52-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
    Bhat et al.
    J.Biol.Chem., 2003;278:45937
  2. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
    Gould et al.
    Int.J.Neuropsychopharmacol., 2004;7:387
  3. GSK3β signalling: casting a wide net in Alzheimer's disease.
    Bhat and Budd
    Neurosignals, 2002;11:251
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AR-A 014418 include:

2 Citations: Showing 1 - 2
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  1. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.
    Authors: Penas Et al.
    Tuberc Respir Dis (Seoul) 2015;14:417
  2. GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
    Authors: Cuesto Et al.
    PLoS One 2015;10:e0118475

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