AR-C155858

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:4960
Chemical Name:6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity
Inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and <10 nM respectively). Exhibits no activity at MCT4. Blocks proliferation of Raji lymphoma cells in vitro. Inhibits glycolysis and glutathione synthesis in cancer cells.
Technical Data
  • M.Wt:
    461.53
  • Formula:
    C21H27N5O5S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    496791-37-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca UK Limited
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AR-C155858 include:

2 Citations: Showing 1 - 2
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  1. Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.
    Authors: Jamali Et al.
    Sci Rep  2015;5:13605
  2. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.
    Authors: Haas Et al.
    Nat Commun  2015;13:e1002202

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Average Rating: 3 (Based on 1 review)

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Images Ratings Applications Species Reviewed By Date Details
 Blocking MCT activity in small intestine 4960 Array 4960
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  Rat Anonymous 02/12/2018
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 Blocking MCT activity in small intestine 4960
: Blocking MCT activity in small intestine [4960].

Summary

Species Rat
Pub Med ID IP under protection

Other Experimental Details

Other Experimental Details Only partial blockage achieved at selected concentration

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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