AR-C155858

Catalog # Availability Size / Price Qty
4960/1
Cat.No. 4960 - AR-C155858 | C21H27N5O5S | CAS No. 496791-37-8
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Description: MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells

Chemical Name: 6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Inhibitor of the monocarboxylate transporters (MCTs) MCT1 and MCT2 (Ki values are 2.3 and <10 nM respectively). Exhibits no activity at MCT4. Blocks proliferation of Raji lymphoma cells in vitro. Inhibits glycolysis and glutathione synthesis in cancer cells.

Technical Data

Formula:
C21H27N5O5S
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
496791-37-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from AstraZeneca UK Limited

Product Datasheets

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Citations for AR-C155858

The citations listed below are publications that use Tocris products. Selected citations for AR-C155858 include:

2 Citations: Showing 1 - 2

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Blocking MCT activity in small intestine
By Anonymous on 02/12/2018
Species: Rat

To transiently block uptake capacity of MCT receptors in small intestine of in an ex vivo rodent model

Only partial blockage achieved at selected concentration


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