Arctigenin

Catalog # Availability Size / Price Qty
1777/10
1777/50
Arctigenin | CAS No. 7770-78-7 | MEK Inhibitors
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Description: Potent MEK1 inhibitor. Also inhibits IκBα phosphorylation
Alternative Names: (-)-Arctigenin

Chemical Name: (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

Technical Data

M.Wt:
372.42
Formula:
C21H24O6
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
7770-78-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation.
    Cho et al.
    Int.Immunopharmacol., 2002;2:105
  2. Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
    Jang et al.
    J.Neurosci.Res., 2002;68:233
  3. Differential in vitro anti-HIV activity of natural lignans.
    Schroder et al.
    Z.Naturforsch.C., 1990;45:1215
  4. Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation.
    Cho et al.
    Exp.Biol.Abstr., 2003;:152.2

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Citations for Arctigenin

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2 Citations: Showing 1 - 2

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