Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of Iκ
phosphorylation and p65 nuclear translocation (IC50
= 10 nM). Inhibits HIV-1 replication in vitro
. Also potently inhibits MKK1 (MEK1) (IC50
= 0.5 nM) and provides neuroprotection by binding to kainate receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation.
Cho et al.
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Jang et al.
Differential in vitro anti-HIV activity of natural lignans.
Schroder et al.
Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation.
Cho et al.
The citations listed below are publications that use Tocris products. Selected citations for Arctigenin include:
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