Chemical Name: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Biological ActivityHigh affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology.
Davies et al.
CNS Drug Rev., 2004;10:317
Usefulness of the dopamine system-stabilizer aripiprazole for reducing morphine-induced emesis.
Shiokawa et al.
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