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ARN 14686

Catalog #: 5862 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5862/10
5862/50
ARN 14686 | CAS No. 1628345-10-7 | General Laboratory Research Reagent
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Description: Potent N-acylethanolamine acid amidase inhibitor; NAAA activity-based protein profiling (ABPP) probe

Chemical Name: (S)-Undec-10-yn-1-yl (2-oxoazetidin-3-yl)carbamate

Purity: ≥98%

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Biological Activity

ARN 14686 is a NAAA (N-acylethanolamine acid amidase) activity-based protein profiling (ABPP) probe. Can be used to detect NAAA in cell lysates or intact cells. Covalently binds the N-terminal cysteine of catalytically active NAAA. Detects catalytically active NAAA in inflamed rat paw in CFA model of inflammation. Potent NAAA inhibitor (IC50 = 6 nM).

Technical Data

M.Wt:
280.36
Formula:
C15H24N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1628345-10-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Activity-based probe for N-acylethanolamine acid amidase.
    Romeo et al.
    ACS Chem.Biol., 2015;10:2057

Product Datasheets

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