Artemether

Key Product Details

Product Description

Artemether is an antimalarial. Prevents cerebral malaria in Plasmodium berghei infected mice. Exhibits synergistic effects with Methylene Blue (Cat. No. 3213) against P. falciparum in vitro. Inhibits neuroinflammation in neuronal/microglial cell co-cultures via induction of Nrf2 expression.

Product Specifications for Artemether

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Artemether

The following data is based on the product molecular weight 298.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Prada Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artem. J.Antimicrob.Chemother. 1996 PMID: 8858461
• Akoachere In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrob.Agents Chemother. 2005 PMID: 16251300
• Okorji Antimalarial drug artem. inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms. Mol.Neurobiol. 2015 PMID: 26607631

Product Documents for Artemether